Identification of tet (B), Encoding High-Level Tetracycline Resistance, in Neisseria meningitidis

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Identification of tet(B), encoding high-level tetracycline resistance, in Neisseria meningitidis.

A Neisseria meningitidis strain, NIID129, with high-level resistance to tetracycline (Tet) was isolated from a Japanese woman’s nasopharynx; the MIC of tetracycline (Pfizer Pharmaceuticals Inc.) was 32 g/ml on Muller-Hinton agar (Difco) as determined by the microdilution method performed in accordance with NCCLS guidelines (6) and 24 g/ml when measured by the Etest (AB Biodisk). In order to det...

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International clone of Neisseria meningitidis serogroup A with tetracycline resistance due to tet(B).

Thirteen Neisseria meningitidis clinical isolates from Africa, Asia, and the United States for which the tetracycline MICs were elevated (> or =8 microg/ml) were examined for 14 recognized resistance genes. Only the drug efflux mechanism encoded by tet(B) was detected. All isolates were in serogroup A, belonged to complex ST-5, and were closely related by pulsed-field gel electrophoresis analysis.

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Plasmid-encoded Tet B tetracycline resistance in Haemophilus parasuis.

The complete sequence of two plasmids, pHS-Tet (5.1 kb) and pHS-Rec (9.5 kb), isolated from Haemophilus parasuis strain HS1543 has been obtained. Plasmid pHS-Tet contains four open reading frames including a tet(B) tetracycline resistance gene which unusually did not have an associated tetR repressor gene. From a total of 45 H. parasuis isolates surveyed (15 international reference strains, 15 ...

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Prevalence of Tetracycline Resistance Genes tet (A, B, C, 39) in Klebsiella pneumoniae Isolated from Tehran, Iran by Multiplex PCR

Background and Objective: Klebsiella pneumoniae is one of the three pathogens that has become a global disease control and treatment problem due to its resistance to common antibiotics. For this reason, it is crucial to study the genes that cause antibiotic resistance in it. Therefore, the aim of this study was to investigate the phenotypic and genotypic frequency of tetracycline resistance in ...

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Antimicrobial susceptibility of Neisseria gonorrhoeae in Zaire: high level plasmid-mediated tetracycline resistance in central Africa.

OBJECTIVE To determine the in vitro antimicrobial susceptibility of gonococcal strains isolated in 1988 among female prostitutes in Kinshasa, Zaire and to characterise strains with high level tetracycline resistance. METHODS Minimal inhibitory concentrations of 8 antimicrobials were measured by agar dilution technique. Plasmid-profiles and serovars were determined. RESULTS Two hundred and t...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 2002

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.46.12.4045-4046.2002